NLSdb provides multiple services concerning nuclear export and localization signals (NES/NLS).
Users can either submit protein sequences to search for potential NES/NLS, or their own NES/NLS sequences to evaluate or compare them against NLSdb.
We also offer the option to simply browse all NES/NLS in NLSdb, as well as downloads for all NES/NLS sequences and (non-)nuclear proteins.
Input: One or more protein sequences in FASTA format.
Searches the sequence(s) for any NES/NLS contained in NLSdb.
Input: One or more UniProt ACs.
Maps the UniProt AC(s) to the corresponding protein sequence(s) and searches the sequence(s) for any NES/NLS contained in NLSdb.
Input: One or more (potential) NES/NLS sequences.
Searches NLSdb for any NES/NLS similar to the query NES/NLS sequence(s).
Input: One or more (potential) NES/NLS sequences.
Evaluates the query NES/NLS based on the number of nuclear and non-nuclear protein sequences it matches (they match).
The original query (FASTA header, UniProt AC, or NES/NLS sequence).
The NES/NLS sequence matched by the query.
The UniProtKB AC of the protein sequence matched by the query.
The type of the signal (NES or NLS).
The type of the protein (nuclear or non-nuclear).
The start position of the match within the sequence.
The end position of the match within the sequence.
The number of nuclear proteins matched by the query.
The number of nuclear protein families matched by the query.
The number of non-nuclear proteins matched by the query.
The evidence annotation for the NES/NLS (by expert, experimental, or potential).
The origin/source of the NES/NLS (in silico mutagenesis, UniProtKB AC, SeqNLS, ValidNESs, or NESbase).
The date the NES/NLS or protein entry was added to NLSdb.
The date the NES/NLS or protein entry was last modified (e.g. number of proteins matched).