Lecture 'Protein Prediction'

 

Type:

Lecture (4 SWS) + Exercise (2 SWS)

Ects:

8.0

Lecturer

Burkhard Rost  (lecture)
Tobias Hamp, Christian Schäfer (exercise)

Rotation:

Tuesday 12:30-14:00 (lecture)
Friday, 10:30-12:00 (lecture)
Friday, 14:45 -16:15 (exercise)

Place:

Lecture: (Multimedia room) 00.13.009A
Exercise: (Praktika room) 01.08.021 change!

except for: Tuesday, April 27th (lecture) --> room "Konrad Zuse" - 01.11.018

 

Language:

English

Content

Topics will include (but not be limited to):

  • Intro: what is protein function?
  • Predicting protein function using sequence: sequence alignments, multiple sequence alignments, motifs, domain assignment, annotation transfer by homology, ab initio predictions.
  • Predicting protein function using structure: structural alignments, structural motifs, annotation transfer via structure similarity.
  • From structure prediction to function prediction: comparative modeling; prediction of: secondary structure, hydrophilicity profiles, solvent accessibility, transmembrane segments, disordered regions, contact maps, functional residues; template free modeling.
  • Machine learning.

Materials

Materials for this lecture and the exercise you can find on the Teaching -> Videos & Materials page.