UniqueProt: Creating representative protein sequence sets.

TitleUniqueProt: Creating representative protein sequence sets.
Publication TypeJournal Article
Year of Publication2003
AuthorsMika, S, Rost, B
JournalNucleic Acids Res
Date Published2003 Jul 1
KeywordsAlgorithms, Internet, Protein Structure, Tertiary, Proteins, Sequence Alignment, Sequence Analysis, Protein, Software, User-Computer Interface

UniqueProt is a practical and easy to use web service designed to create representative, unbiased data sets of protein sequences. The largest possible representative sets are found through a simple greedy algorithm using the HSSP-value to establish sequence similarity. UniqueProt is not a real clustering program in the sense that the 'representatives' are not at the centres of well-defined clusters since the definition of such clusters is problem-specific. Overall, UniqueProt is a reasonable fast solution for bias in data sets. The service is accessible at http://cubic.bioc.columbia.edu/services/uniqueprot; a command-line version for Linux is downloadable from this web site.

Alternate JournalNucleic Acids Res.
PubMed ID12824419
PubMed Central IDPMC169026
Grant List1-R01-LM07329-01 / LM / NLM NIH HHS / United States
R01-GM63029-01 / GM / NIGMS NIH HHS / United States