Beyond annotation transfer by homology: novel protein-function prediction methods to assist drug discovery.

TitleBeyond annotation transfer by homology: novel protein-function prediction methods to assist drug discovery.
Publication TypeJournal Article
Year of Publication2005
AuthorsOfran, Y, Punta, M, Schneider, R, Rost, B
JournalDrug Discov Today
Volume10
Issue21
Pagination1475-82
Date Published2005 Nov 1
ISSN1359-6446
KeywordsComputational Biology, Databases, Protein, Drug Design, Evolution, Molecular, Genome, Proteins, Sequence Homology
Abstract

Every entirely sequenced genome reveals 100 s to 1000 s of protein sequences for which the only annotation available is 'hypothetical protein'. Thus, in the human genome and in the genomes of pathogenic agents there could be 1000 s of potential, unexplored drug targets. Computational prediction of protein function can play a role in studying these targets. We shall review the challenges, research approaches and recently developed tools in the field of computational function-prediction and we will discuss the ways these issues can change the process of drug discovery.

DOI10.1016/S1359-6446(05)03621-4
Alternate JournalDrug Discov. Today
PubMed ID16243268
Grant ListR01-GM64633-01 / GM / NIGMS NIH HHS / United States
R01-LM07329-01 / LM / NLM NIH HHS / United States