# A modified definition of Sov, a segment-based measure for protein secondary structure prediction assessment

 Title A modified definition of Sov, a segment-based measure for protein secondary structure prediction assessment Publication Type Journal Article Year of Publication 1999 Authors Zemla, A, Venclovas, C, Fidelis, K, Rost, B Journal Proteins Volume 34 Pagination 220-3 Keywords *Algorithms *Protein Structure, Secondary Abstract We present a measure for the evaluation of secondary structure prediction methods that is based on secondary structure segments rather than individual residues. The algorithm is an extension of the segment overlap measure Sov, originally defined by Rost et al. (J Mol Biol 1994;235:13-26). The new definition of Sov corrects the normalization procedure and improves Sov's ability to discriminate between similar and dissimilar segment distributions. The method has been comprehensively tested during the second Critical Assessment of Techniques for Protein Structure Prediction (CASP2). Here, we describe the underlying concepts, modifications to the original definition, and their significance.