Structure prediction of proteins–where are we now?

TitleStructure prediction of proteins–where are we now?
Publication TypeJournal Article
Year of Publication1994
AuthorsRost, B, Sander, C
JournalCurr Opin Biotechnol
Volume5
Pagination372-80
KeywordsAmino Acid Sequence Biochemistry/trends *Computer Simulation Databases, Factual *Models, Molecular Molecular Sequence Data *Protein Conformation Protein Structure, Secondary Sequence Alignment/methods
Abstract

Although the 'structure from sequence' prediction problem remains fundamentally unsolved, new and promising methods in one, two and three dimensions have reopened the field. Significantly improved one-dimensional prediction of secondary structure from multiple sequence alignments is now in routine use. In the two-dimensional approach, inter-residue contacts can be detected by analysis of correlated mutations, albeit with low accuracy. Finally, three-dimensional methods, in which pseudopotentials or information values are derived from the databases, are proving their value for distinguishing between correct and incorrect models.