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Title | Structure prediction of proteins–where are we now? |
Publication Type | Journal Article |
Year of Publication | 1994 |
Authors | Rost, B, Sander, C |
Journal | Curr Opin Biotechnol |
Volume | 5 |
Pagination | 372-80 |
Keywords | Amino Acid Sequence Biochemistry/trends *Computer Simulation Databases, Factual *Models, Molecular Molecular Sequence Data *Protein Conformation Protein Structure, Secondary Sequence Alignment/methods |
Abstract | Although the 'structure from sequence' prediction problem remains fundamentally unsolved, new and promising methods in one, two and three dimensions have reopened the field. Significantly improved one-dimensional prediction of secondary structure from multiple sequence alignments is now in routine use. In the two-dimensional approach, inter-residue contacts can be detected by analysis of correlated mutations, albeit with low accuracy. Finally, three-dimensional methods, in which pseudopotentials or information values are derived from the databases, are proving their value for distinguishing between correct and incorrect models. |