# Structure prediction of proteins–where are we now?

 Title Structure prediction of proteins–where are we now? Publication Type Journal Article Year of Publication 1994 Authors Rost, B, Sander, C Journal Curr Opin Biotechnol Volume 5 Pagination 372-80 Keywords Amino Acid Sequence Biochemistry/trends *Computer Simulation Databases, Factual *Models, Molecular Molecular Sequence Data *Protein Conformation Protein Structure, Secondary Sequence Alignment/methods Abstract Although the 'structure from sequence' prediction problem remains fundamentally unsolved, new and promising methods in one, two and three dimensions have reopened the field. Significantly improved one-dimensional prediction of secondary structure from multiple sequence alignments is now in routine use. In the two-dimensional approach, inter-residue contacts can be detected by analysis of correlated mutations, albeit with low accuracy. Finally, three-dimensional methods, in which pseudopotentials or information values are derived from the databases, are proving their value for distinguishing between correct and incorrect models.