[Locoregional intra-arterial chemotherapy of primary incurable local recurrence of breast cancer]

Title[Locoregional intra-arterial chemotherapy of primary incurable local recurrence of breast cancer]
Publication TypeJournal Article
Year of Publication1993
AuthorsNitz, U, Havenith, B, Rost, B, Mosny, D, Ellerbrok, G
JournalGeburtshilfe Frauenheilkd
Volume53
Pagination760-7
KeywordsAdjuvant Combined Modality Therapy Female Humans *Infusions, Adult Aged Antineoplastic Combined Chemotherapy Protocols/adverse effects/*therapeutic use Breast Neoplasms/*drug therapy/mortality/pathology Chemotherapy, Intra-Arterial Middle Aged Neoplasm Recurrence, Local/*drug therapy/mortality/pathology Neoplasm Staging Survival Rate
Abstract

Approximately one third of all local recurrences of breast cancer are incurable at the time of diagnosis. Locoregional intraarterial chemotherapy is one of the new therapy modalities besides laser therapy and combined radiotherapy/hyperthermia. The results of a phase I-II study, in which 15 patients with advanced, partly pretreated local recurrences as well as 2 patients with T4N2/N3 tumours were included, are reported as follows. All in all, 39 superselective intraarterial chemotherapy courses were carried out. Mitomycin (10 mg) and Mitoxantrone (25 mg) were infused over 90 min. The side effects due to the catheter system were two haematomas and one thrombosis attributed to an insufficient heparin dose. Locally, the chemotherapy was well tolerated. One severe systemic side effect, a leucopenia WHO 4 degrees was observed. Nausea, thrombocytopenia and alopecia rates were low (7 x nausea 1 degree, 5 x thrombocytopenia 1 degree, 2 x thrombocytopenia 2 degrees, 2 x alopecia 1 degree). 6 Complete remissions (3 x pCR, 3 x cCR) as well as 6 partial remissions and 5 no changes were found. We believe that this method, because of the low side-effect profile and the temporary good results, represents a good alternative in otherwise incurable locoregional recurrence of breast carcinoma and in specified cases of locally advanced disease. 1 degree and 2 x thrombocytopenia 2 degrees, 2 x alopecia 1 degree). Altogether, 6 complete remissions were found (3 x cCR, 3 x pCR), 6 partial remissions with 4 x no change occurred.(ABSTRACT TRUNCATED AT 250 WORDS)