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Type: |
Lecture (4 SWS) + Exercise (2 SWS) |
---|---|
Ects: |
8.0 |
Lecturer |
Burkhard Rost (lecture) |
Rotation: |
Tuesday, 12:30 - 14:00 (lecture) |
Place: |
Lecture: MI 01.09.034 Exercise: MI 01.09.034 Exam: Maschinenwesen 5505.03.502 (3rd floor) Time: 11.30 - 13.30 Exam review: 23.2. at 15.15 in Tanya's/Jonas's office |
Language: |
English |
Announcements: |
The latest news are always on top! NEW!!!! Thursday, Oct. 22nd 2015: Due to health reasons the lecture of Prof. Rost must be cancelled. The exercise takes place. Examen: XXXX (Important: Don't forget to register at TUMonline for the exam)
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This lecture continues the 'Protein Prediction' lecture. The attendance of this lecture is however not a mandatory requrement for 'Protein Prediction II'.Topics will include (but not be limited to):
Nov 3rd Introduction to Protein Function - Video: YouTube (1080p) , Download (360p)
Nov 3rd Predict PPIs through expression - Video: YouTube (1080p)
Nov 12th Function Prediction - Video: YouTube (1080p)
Nov 17th CAFA (now with correct slides - thanks to D.N.) - Videos: Download (720p)
Nov 19th Enzymes - Videos: Download (480p)
Nov 24th Localization - Video: YouTube (1080p), YouTube part 2 (1080p)
Dec 8th Localization Protein-Protein Interaction
Jan 7th Protein-Protein Interaction Sites - Video: YouTube (1080p)
Jan 12th Protein-Protein Pairs - Video: Download (480p)
Jan 19th SNPs - Video: YouTube (1080p)
Millions of single nucleotide variations are estimated to exist between people. Each one may result in no effect at all or any effect up to single-handedly leading to the development of fatal diseases. Methods have been developed that try to predict the effect at varying levels, i.e. anything from "molecular effect" to "leads to a disease".
In the first part of this exercise you will evaluate three methods' effect predictions for every possible variant in the complete human proteome. In the second part of the exercise you will focus on one tool (SNAP2) and evaluate how the predicted effect in the whole proteome differs between a set of model organism ranging from viruses over archaea to complex eukaryotes.
In parallel, we will run also another project where we will try to predict protein-protein interactions from human microarray data.
For more details please refer to our wiki. The organisation, requirements and grading of the exercise are also explained there.The log in credentials will be announced in the exercise on Oct 22, 2015.