ID   MIX_00350
AC   350
CL   MIX
DT   30-AUG-2003
UD   05-JUL-2004 (chop and predictions added)
UD   12-JUL-2004 (NMTS-homology added)
NA   Glucocorticoid receptor
NA   GR
GN   NR3C1
GN   GRL
GN   GRL1
OS   Mus musculus (Mouse)
P1   10848625 (2007)
P2   1659997 (1991), 2717578 (1989), 3528149 (1962), 3729932 (1986), 8628265 (2001), 10813393 (2000), 9353307 (1997), 9731709 (1998), 12024025 (2002), 10848625 (2007)
SP   GCR_MOUSE, P06537
KW   Alternative initiation, Alternative splicing, DNA-binding, Nuclear protein, Phosphorylation, Receptor, Steroid-binding, Trans-acting factor, Transcription regulation, Ubl conjugation, Zinc-finger
FN   Receptor for glucocorticoids (GC). Has a dual mode of action: as a transcription factor that binds to glucocorticoid response elements (GRE) and as a modulator of other transcription factors. Affects inflammatory responses, cellular proliferation and differentiation in target tissues. 
GB   CAA28031.1, CAA31738.1, CAA31739.1
SS   SWISSPROT/TrEMBL
SI   783 AA; 86052 Da; calculated pI: 5.99
SQ   MDSKESLAPPGRDEVPSSLLGRGRGSVMDLYKTLRGGATVKVSASSPSVAAASQADSKQQRILLDFSKGSASNAQQQQQQQQPQPDLSKAVSLSMGLYMGETETKVMGNDLGYPQQGQLGLSSGETDFRLLEESIANLNRSTSRPENPKSSTPAAGCATPTEKEFPQTHSDPSSEQQNRKSQPGTNGGSVKLYTTDQSTFDILQDLEFSAGSPGKETNESPWRSDLLIDENLLSPLAGEDDPFLLEGDVNEDCKPLILPDTKPKIQDTGDTILSSPSSVALPQVKTEKDDFIELCTPGVIKQEKLGPVYCQASFSGTNIIGNKMSAISVHGVSTSGGQMYHYDMNTASLSQQQDQKPVFNVIPPIPVGSENWNRCQGSGEDNLTSLGAMNFAGRSVFSNGYSSPGMRPDVSSPPSSSSTATGPPPKLCLVCSDEASVCHYGVLTCGSCKVFFKRAVEGQHNYLCAGRNDCIIDKIRRKNCPACRYRKCLQAGMNLEARKTKKKIKGIQQATAGVSQDTSENANKTIVPAALPQLTPTLVSLLEVIEPEVLYAGYDSSVPDSAWRIMTTLNMLGGRQVIAAVKWAKAIPGFRNLHLDDQMTLLQYSWMFLMAFALGWRSYRQASGNLLCFAPDLIINEQRMTLPCMYDQCKHMLFISTELQRLQVSYEEYLCMKTLLLLSSVPKEGLKSQELFDEIRMTYIKELGKAIVKREGNSSQNWQRFYQLTKLLDSMHDVVENLLSYCFQTFLDKSMSIEFPEMLAEIITNQIPKYSNGNIKKLLFHQK
SE   LLLLLLLLLLLLLLLLLLLLLLLLLLHHHHLLLLLLLLEEEEELLLLLLLLLLLLLLLLLLLLLLLLLLLLLLLLLLLLLLLLLHHHLLLEEEELLLLLLLLLLLLLLLLLLLLLLLLLLLLLLLLLLLLLLLLLLLLLLLLLLLLLLLLLLLLLLLLLLLLLLLLLLLLLLLLLLLLLLLLLLLLLLLLLLLLLLLLLLLLLLLLLLLLLLLLLLLLLLLLLLLLLLLLLLLLLLLLLLLLEELLLLLLLLLLLLLLLLLLLLLLLLLLLLLLLLLLLLLLLLLLLLLLLLLLLLLLLLLLLLLLLLLLLLLLLLLLLLLLLLLLLLLLLLLLLLLLLLLLLLLLLLLLLLLLLLLLLLLLLLLLLLLLLLLLLLLLLLLLLLLLLLLLLLLLLLLLLLLLLLLLLLLLLLLLLLLLLLLLLLLEEEEEELLLLLLLLLLEELLHHHHHHHHHHHLLLLLEELLLLLLLLLLLLLLLLLHHHHHHHHHHHLLLLLLEELLLLLLLLLLLLLLLLLLLLLLLLLLLLLLLLLLLLHHHHHHHHHLLLLEEELLLLLLLLLLHHHHHHHHHHHHHHHHHHHHHHHHHLLLLLLLLHHHHHHHHHHHHHHHHHHHHHHHLLLLLLLLEEEELLLLLLLLLLLLHHHHHHHHHHHHHHHHHHHHLLLLLHHHHHHEEEEEELLLLLLLLLLHHHHHHHHHHHHHHHHHHHHHLLLLLLLLHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHLLLLLLHHHHHHHHHHLLLLLLLLLLLLEEEELL
SA   eebeebbieeeeeebibbbbeeeeeibbebbibbieebibibebeiebbbbbeeeeeeeiiibbebeeebeebbeebbibieibeebbebbbbbbbbbbebbebiiieeebeieeeeebbbbiiieebibbeebbeebeibieieeieeeebeebeeeeeeieeiieeieebbeeieeeeeieeeeeeibebbbeeebieebieebebbeeieeeebeeeebibebbeeebbbieieeeebbbbbeeeeeeeieeeeieeeeeebeeeeeeieeiieebebeeeeeeeeebbebbieebbeieeeeeibbibeieibeiieieiiebbeebbeieeeibiiieeeiebbiieieeeeieibbiibieieeeieeeeeieeeeeieeeeeeeeeieibeeeeeeeebieeeeeeeeeeeeeeeeeebbbbbbbbibbbibbbbbbbebbibbbiibbieibibbbibieibbbbieiieibbbbbbiibbbbbbiiebbieeieeeeeeeeeeeeeeeeeeeeeeeeiieebeibbeebbbbbbebiiebbbbieeeeieebebibbbbbbibbeibbbbbbibbeibbbbbibbbibbbbbbibbbbbbbbbbbbbbbbeieeeibbbbbbbbbbiieibibbbbbibbibbbibbeibiibibieeibbbbbbbbbbbbibiebbeeieibiebbeibbebbiebbbeeieeeeeibiibbibbbbbibbiibbeebbebbbibbbibibebbbbibbbibbebibbebbeeebibbbbbee
HT   ---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
CO   ---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
NO   ------------------------------------------nnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnn--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
NL   100
DO   #1; AA 27-409; homologue=PF02155.5(1-386); eval=8.6e-274; method=HMMER/Pfam_ls
DO   #2; AA 428-493; homologue=2nllA1(1-66); eval=8e-16; method=BLAST/prism_trim
DO   #3; AA 494-529; homologue=NULL; eval=NULL; method=NULL
DO   #4; AA 530-728; homologue=1l2iB1(3-195); eval=3e-20; method=BLAST/prism_trim
DO   #5; AA 729-783; homologue=NULL; eval=NULL; method=NULL
PT   MIX_00302 (hssp=74.92)
CC   this NMTS is a close homologue (hssp >= 10) to NMTS found in literature
AT   395-562 (DO #2,#3,#4) (alignment)
NT   SVFSNGYSSPGMRPDVSSPPSSSSTATGPPPKLCLVCSDEASVCHYGVLTCGSCKVFFKRAVEGQHNYLCAGRNDCIIDKIRRKNCPACRYRKCLQAGMNLEARKTKKKIKGIQQATAGVSQDTSENANKTIVPAALPQLTPTLVSLLEVIEPEVLYAGYDSSVPDSA
//