Type:	Lecture (4 SWS) + Exercise (2 SWS)
Ects:	8.0
Lecturer	Burkhard Rost  (lecture) Tobias Hamp, Christian Schäfer, Esmeralda Vicedo (exercise)
Rotation:	Wednesday 12:00-13:30 (lecture) Friday, 10:30-12:00 (lecture) Friday, change (!): 13:30-15:00 (exercise)
Place:	Lecture: (Multimedia room) MI 00.13.009A Exercise: (Seminar room 'John von Neumann') MI 00.11.038
Language:	English
Announcements:	Note (!) starting Nov 12 friday's lecture will be held in room 00.08.038 The videos can now be downloaded on this page No Lecture: Dec 22 Last Lecture: Feb 2 Examen: Feb 9,12:00 (MI 00.13.009A, Multimedia room) Makeup: May 6

This lecture continues the 'Protein Prediction' lecture. Topics will include (but not be limited to):

• Predicting protein function using sequence: sequence alignments, multiple sequence alignments, motifs, domain assignment, annotation transfer by homology, ab initio predictions.
• Predicting protein function using structure: structural alignments, structural motifs, annotation transfer via structure similarity.
• From structure prediction to function prediction: comparative modeling; prediction of: secondary structure, hydrophilicity profiles, solvent accessibility, transmembrane segments, disordered regions, contact maps, functional residues; template free modeling.
• Machine learning.

pp2_201010120_our-work.pdf Lecture 1 (10-20-2010)	13.0 M
pp2_20101103_intro_func1.pdf Lecture 4 (11-03-2010)	12.0 M
pp2_20101112_intro_func2.pdf Lecture 6 (11-12-2010)	5.0 M
pp2_20101117_intro_func3.pdf Lecture 7 (11-17-2010)	3.1 M
pp2_20101203_localization1.pdf Lecture 10 (12-03-2010)	5.8 M
pp2_20101208_localization2.pdf Lecture 11 (12-08-2010)	4.1 M
pp2_20110128_snap.pdf Lecture 16 (01-28-2011)	6.9 M

pp2_20101020.mp4 Lecture 1 (10-20-2010)	329 M
pp2_20101027.mp4 Lecture 2 (10-27-2010)	289 M
pp2_20101029.mp4 Lecture 3 (10-29-2010)	258 M
pp2_20101103.mp4 Lecture 4 (11-03-2010)	151 M
pp2_20101110.mov Lecture 5 (11-10-2010) - Jenny Gu	214 M
pp2_20101112.avi Lecture 6 (11-12-2010)	323 M
pp2_20101117.mov Lecture 7 (11-17-2010)	256 M
pp2_20101126.mp4 Lecture 8 (11-26-2010)	265 M
pp2_20101201.avi Lecture 9 (12-01-2010)	316 M
pp2_20101203.avi Lecture 10 (12-03-2010)	256 M
pp2_20101208.wmv Lecture 11 (12-08-2010)	258 M
pp2_20101215.wmv Lecture 12 (12-15-2010) - Prof. Dr. Christopher Baker	302 M
pp2_20110119.wmv Lecture 13 (01-19-2011) - Dr. Marco De Vivo (part 1/2)	523 M
pp2_20110121.mp4 Lecture 14 (01-21-2011) - Dr. Marco De Vivo (part 2/2)	337 M
pp2_20110126.mp4 Lecture 15 (01-26-2011)	400 M
pp2_20110128.mp4 Lecture 16 (01-28-2011)	437 M

exercise1.pdf Sheet 1	72 K
exercise2.pdf Sheet 2	74 K
exercise3_V4.pdf Sheet 3 Version 4	116 K
exercise4_V2.pdf Sheet 4 Version 2	102 K