Type:	Lecture (4 SWS) + Exercise (2 SWS)
Ects:	8.0
Lecturer	Burkhard Rost (lecture) Tobias Hamp, Christian Schäfer, Esmeralda Vicedo (exercise)
Rotation:	Tuesday 13:15 - 14:45 (lecture) Thursday, 10:00 - 11:30 (lecture) Thursday, 11:30 - 12:15 (exercise)
Rooms:	Lecture: 01.09.034 (Tue), 01.11.018 'Konrad Zuse room' (Thu) Exercise: 01.08.021 (Computer room), starting at May 5
Language:	English
Announcements:	No lecture: Tue May 10, Tue May 31, Thu Jun 16, Tue July 5, Thu July 7 Last lecture: Thu Jul 7 Examen (written): Jul 12, 13:15-14:45 (01.09.034) Makeup: likely: October 13 - morning NEWS: Exam inspection Sep 19, 2-3 pm

Content

Topics will include (but not be limited to):

Intro: what is protein function?
Predicting protein function using sequence: sequence alignments, multiple sequence alignments, motifs, domain assignment, annotation transfer by homology, ab initio predictions.
Predicting protein function using structure: structural alignments, structural motifs, annotation transfer via structure similarity.
From structure prediction to function prediction: comparative modeling; prediction of: secondary structure, hydrophilicity profiles, solvent accessibility, transmembrane segments, disordered regions, contact maps, functional residues; template free modeling.
Machine learning.

Materials

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